Frank M Ruemmele Selected Research

X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation

1/2021	Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.
5/2007	Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene.
8/2005	Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome).

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Frank M Ruemmele Research Topics

Disease

20	Crohn Disease (Crohn's Disease) 01/2021 - 03/2008
15	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/2022 - 08/2011
6	Ulcerative Colitis 01/2021 - 03/2009
5	Pediatric Crohn's disease 01/2022 - 07/2004
5	Neoplasms (Cancer) 10/2021 - 02/2014
5	Infections 05/2021 - 02/2014
5	Colitis 01/2021 - 06/2006
4	Necrosis 05/2021 - 10/2011
4	COVID-19 05/2021 - 01/2020
4	Celiac Disease (Celiac Sprue) 01/2018 - 09/2003
3	Inflammation (Inflammations) 01/2021 - 01/2013
3	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 01/2021 - 08/2005
3	Autoimmune enteropathy 01/2018 - 01/2011
2	Microvillus inclusion disease 01/2022 - 10/2008
2	Liver Diseases (Liver Disease) 01/2021 - 01/2016
2	Autoimmune Diseases (Autoimmune Disease) 10/2015 - 08/2011
1	Thromboembolism 06/2022
1	Pathologic Constriction (Stenosis) 10/2021
1	Diarrhea 01/2021
1	Chronic Granulomatous Disease 01/2021
1	Sclerosing Cholangitis 01/2021
1	Intestinal Diseases (Diseases, Intestinal) 01/2021
1	Pediatric ulcerative colitis 01/2021
1	Rheumatic Diseases (Rheumatism) 01/2020
1	Disease Progression 01/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2020
1	Fistula 11/2018
1	Hypersensitivity (Allergy) 01/2018
1	Wheat Hypersensitivity (Wheat Allergy) 01/2018
1	Rare Diseases (Rare Disease) 01/2018
1	Pouchitis 01/2018
1	Abdominal Pain (Pain, Abdominal) 01/2018
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 01/2017
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2017
1	Trichohepatoenteric Syndrome 01/2016
1	Sepsis (Septicemia) 01/2016
1	Cysts 01/2016
1	Intestinal Failure 01/2016
1	Failure to Thrive 10/2015
1	Osteoporosis 10/2015
1	Body Weight (Weight, Body) 04/2015
1	Infertility (Sterility) 01/2014
1	Virus Diseases (Viral Diseases) 12/2013

Drug/Important Bio-Agent (IBA)

8	Immunologic Factors (Immunomodulators)IBA 05/2021 - 03/2009
8	Adalimumab (Humira)FDA Link 01/2021 - 04/2015
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2006
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 04/2015
4	Azathioprine (Imuran)FDA LinkGeneric 01/2021 - 10/2011
4	SteroidsIBA 01/2021 - 10/2011
4	Biological ProductsIBA 01/2021 - 03/2009
4	Infliximab (Remicade)FDA Link 01/2017 - 07/2004
3	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021 - 02/2014
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 07/2019
3	AntibodiesIBA 01/2020 - 01/2013
3	Interleukin-10 (Interleukin 10)IBA 02/2014 - 08/2011
2	Myosins (Myosin)IBA 01/2022 - 10/2008
2	Mesalamine (Mesalazine)FDA LinkGeneric 05/2021 - 01/2020
2	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 01/2020
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2021 - 01/2020
2	AlbuminsIBA 01/2021 - 04/2015
2	C-Reactive ProteinIBA 01/2021 - 04/2015
2	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2018 - 03/2015
2	Glutens (Glutelin)IBA 01/2018 - 10/2015
2	2-mercaptopurineIBA 01/2017 - 10/2011
2	TransferasesIBA 01/2013 - 10/2011
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2013 - 08/2011
1	vinyltriethoxysilane (VTES)IBA 06/2022
1	ChloridesIBA 10/2021
1	Hemoglobins (Hemoglobin)IBA 01/2021
1	Angiotensin-Converting Enzyme 2IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2020
1	Tumor Necrosis Factor InhibitorsIBA 01/2020
1	Food IngredientsIBA 01/2019
1	CarbohydratesIBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	Interleukin-10 ReceptorsIBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	SugarsIBA 01/2016
1	Biosimilar PharmaceuticalsIBA 10/2015
1	TransglutaminasesIBA 10/2015
1	Monoclonal AntibodiesIBA 04/2015
1	AutoantibodiesIBA 02/2014
1	Immunoglobulins (Immunoglobulin)IBA 01/2013
1	Peptides (Polypeptides)IBA 01/2013
1	Tuberculin (PPD)IBA 01/2013

Therapy/Procedure

13	Therapeutics 05/2021 - 03/2008
7	Enteral Nutrition (Feeding, Tube) 07/2019 - 03/2009
5	Colectomy 10/2021 - 03/2009
3	Parenteral Nutrition 01/2021 - 06/2006
2	Transplantation 01/2021 - 04/2004
2	Hematopoietic Stem Cell Transplantation 01/2018 - 01/2018
1	Ileostomy 10/2021
1	Biological Therapy 01/2020
1	Mechanical Ventilators (Ventilator) 01/2020
1	Ambulatory Care (Outpatient Care) 01/2018
1	Catheters 01/2016
1	Gluten-Free Diet 10/2015